Pathophysiologic glucocorticoid elevations promote bacterial translocation after thermal injury
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چکیده
منابع مشابه
Effects of the angiotensin converting enzyme inhibitor enalapril on bacterial translocation after thermal injury and bacterial challenge.
Burn injury and sepsis produce acute gastrointestinal derangements that may predispose patients to bacterial translocation. We studied the effects of enalapril, an angiotensin converting enzyme inhibitor (ACEI), on gastrointestinal anatomic alterations, bacterial translocation, and related mortality during gut-derived sepsis in burned mice that had received a prior bacterial challenge. BALB/c m...
متن کاملMicrobial Translocation in Thermal Injury
Cutaneous injury by thermal burns in experimental animals produces a highly reproducible acute model for studying the barrier function of the intestine wherein the magnitude of microbial translocation is directly associated with the extent of injury. Translocation after burn occurs throughout the intestinal tract with extreme rapidity, reaches an early peak within hours, and then has a less int...
متن کاملExperimental candidiasis after thermal injury.
The ability of Candida albicans to infect thermally injured mice was studied. Female mice were either left unburned or given a 20% total body surface area 2-s or 7-s scald burn. The wound or skin surface was then inoculated with a human burn wound isolate of C. albicans. At 4 h postburn, approximately 10(2) to 10(3) CFU/g of tissue could be recovered from the skin of burned and unburned animals...
متن کاملEnhancing apoptotic cell clearance mitigates bacterial translocation and promotes tissue repair after gut ischemia-reperfusion injury
A key aspect of intestinal ischemia/reperfusion (I/R) injury is the increased occurrence of apoptotic cell death in the gut. Insufficient clearance of apoptotic cells leads to increased inflammation and impaired tissue repair. Our recent studies have shown that administration of milk fat globule-epidermal growth factor-factor 8 (MFG-E8), a crucial molecule for apoptotic cell clearance, reduces ...
متن کاملN-acetylcysteine attenuates bacterial translocation after partial hepatectomy in rats.
BACKGROUND Translocating enteric bacteria have been suggested as playing a major role in the development of infections after partial hepatectomy. We investigated the effect of N-acetylcysteine (NAC) on bacterial translocation (BT) and intestinal mucosa as the first line of defense against BT. MATERIALS AND METHODS We compared four groups of eight Sprague-Dawley male rats each: sham, control (...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1990
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.58.10.3257-3261.1990